Journal article
A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study
CRZ See, S Si, CL Baird, CC Haswell, A Hussain, M Olff, DJ Veltman, JL Frijling, M Van Zuiden, SBJ Koch, L Nawijn, L Wang, Y Zhu, G Li, Y Neria, X Zhu, B Suarez-Jimenez, S Zilcha-Mano, A Lazarov, JS Stevens Show all
European Psychiatry | Published : 2025
Abstract
Background. Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group. Methods. T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volume..
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Awarded by Deutsche Forschungsgemeinschaft
Awarded by Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions